Under normal conditions, the brain depends almost entirely on glucose for energy. This glucose comes from carbohydrates in the diet and stored glycogen in the liver. Glycogen Depletion :When a person fasts or drastically reduces carbohydrate intake, the body quickly uses up its glycogen stores—usually within about 24 hours. Once this reserve is exhausted, the body must find another fuel source. Ketone Production: Because fatty acids cannot directly cross the blood–brain barrier , the liver converts them into smaller, water-soluble molecules called ketone bodies :Beta-hydroxybutyrate, Acetoacetate, Acetone.These ketones can easily enter the brain and replace glucose as the primary fuel. This metabolic state is called ketosis , and it fundamentally changes how brain cells function. How Ketones Help Prevent Seizures Ketones don’t just provide energy—they actively stabilize brain activity. Their anti-seizure effects occur through multiple biological mechanisms. Restoring Neurotransmitter ...